Plasma Levels of Transforming Growth Factor-Beta 1 in Women with Pelvic Organ Prolapse

Objective: In women with pelvic organ prolapse (POP), decreased expression of transforming growth factor-beta 1 (TGF-β1) has been shown in POP tissues. However, no studies have evaluated plasma TGF-β1 levels patients POP, so it is unknown whether they are also changed or not. Therefore, we compared and without POP. Methods: Participants were 49 23 healthy control women. All participants postmenopausal. We measured data between controls, uterine (UP, n = 19) those a cystocele (CC, 30). addition, patients, assessed the quantification system (POP-Q) stage. Results: Plasma significantly lower than controls. POP-Q stage was not different UP CC subgroups, but IV diagnosed 63% 7% CC. subgroup subgroup. Conclusion: It remains unclear indicate reduction systemic activity, can be assumed to reflect reduced